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HomeBusinessBayer Halts Phase III Trial On Once-promising Blood Clot Medication

Bayer Halts Phase III Trial On Once-promising Blood Clot Medication

HEALTH- German pharmaceutical giant Bayer has halted a study on the anti-coagulant Asundexian early after data showed poor performance.

The drug had been seen as a promising potential treatment from Bayer and was viewed as the likely successor to Xarelto, the brand name of Bayer’s Rivaroxaban medication which is widely prescribed by doctors to prevent and treat blood clots.

Asundexian was in relatively advanced stage III trials, and there were expectations at Bayer that Asundexian could eventually generate billions of dollars in annual revenue for Bayer.

There is a large and booming market for anticoagulants, which are often prescribed for older patients to reduce the risk of strokes.

But early data from the study indicated that it was less effective than the standard treatment, the company said on Monday. Bayer said it will continue to analyse the data.

The company had only recently extended the phase III study programme for Asundexian. Medications that clear a stage III trial and relatively close to regulatory approval.

Xarelto has been one of Bayer’s most lucrative pharmaceutical products, generating €3 billion ($3.3 billion) in sales over the first nine months of 2023. That accounted for about a quarter of all revenue in the pharmaceutical division.

However, Bayer’s lucrative patent protections for Xarelto will gradually expire over the coming years. Far cheaper generic competitors are already available in Brazil, and should arrive on other markets as the company’s patents expire.

Xarelto sales were down 8.4% over the first nine months of 2023, which the company attributed to growing price pressure from other drugs.

Credit: dpa.

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